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Application of N,N,N’,N’-Tetramethyl-p-phenylenediamine dihydrochloride_Kain Industrial Additive
Background and overview[1][2] N,N,N’,N’-tetramethyl-p-phenylenediamine dihydrochloride, also called tetramethyl-p-phenylenediamine hydrochloride, or TMPD for short, is an oxidase reagent t…
Preparation and application of 4-iodo-2,6-dimethylaniline_Kain Industrial Additive
Background and overview[1] 4-Iodo-2,6-dimethylaniline is an organic intermediate that can be prepared from iodination of 2,6-dimethylaniline. The amino group of 4-iodo-2,6-dimethylaniline can be diazo…
Preparation of 3′-bromo-4′-methylacetophenone_Kain Industrial Additive
Background and overview[1] 3′-Bromo-4′-methylacetophenone is a bromide of acetophenone derivatives. This type of compound is a very important chemical intermediate in medicines, pesticides…
Preparation and application of 2-amino-4-bromobenzaldehyde_Kain Industrial Additive
Background and overview[1] 2-Amino-4-bromobenzaldehyde can be used as a pharmaceutical synthesis intermediate, which can be prepared by reaction with 2-amino-4-bromobenzoic acid as the starting materi…
Preparation of 3-bromo-2-methylbenzaldehyde_Kain Industrial Additive
Background and overview[1][2] 3-Bromo-2-methylbenzaldehyde can be used as a pharmaceutical synthesis intermediate, which can be reduced from 3-bromo-2-methylbenzoic acid as the starting material to ob…
Preparation of 4-(4-methylpiperazine)aniline_Kain Industrial Additives
Background and overview[1] 4-(4-methylpiperazine)aniline can be used as a pharmaceutical intermediate. It can be prepared by reducing p-fluoronitrobenzene with N-methylpiperazine after nucleophilic su…
Preparation of 4-hydroxy-3-methoxy-2-nitrobenzaldehyde_Kain Industrial Additive
Background and overview[1] 4-Hydroxy-3-methoxy-2-nitrobenzaldehyde can be used as a pharmaceutical intermediate, which can be prepared through a three-step reaction using vanillin as the starting mate…
Preparation of 5,6-diphenyl-2-hydroxypyrazine_Kain Industrial Additive
Background and overview[1] 5,6-Diphenyl-2-hydroxypyrazine is a pharmaceutical intermediate that can be prepared in one step from benzoyl and aminoacetamide hydrochloride. There are reports in the lite…
Preparation of (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone_Kain Industrial Additive
Background and overview[1] (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone, referred to as (-)β-lactam, is a very potential chiral drug intermediate. There are two isomers, namely (3R, 4S) configuration and …
Preparation of (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-3,5-oxazolidinedicarboxylic acid 3-tert-butyl ester_Kain Industrial Additive
Background and overview[1] (4S,5R)-2-(4-Methoxyphenyl)-4-phenyl-3,5-oxazolidinedicarboxylic acid 3-tert-butyl ester is a pharmaceutical intermediate, which can be made from ( 2′R,3′S)-phenylisoserine …
