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Preparation of 3,3’5,5′-tetramethylbiphenyl bisphenol diglycidyl ether_Kain Industrial Additive
Background and overview[1][2] Electronic materials are the basis for the development of the microelectronics industry. As the main structural material for the production of integrated circuits, epoxy …
Preparation of 2-bromo-3′-chloropropiophenone_Kain Industrial Additive
Background and overview[1][2] Rimonabant is a new type of weight-loss drug. 2-Bromo-3′-chloropropiophenone is the key intermediate for the synthesis of rimonabant. Currently, there are very few …
Preparation of 2-bromo-1-chloro-4-trifluoromethoxybenzene_Kain Industrial Additive
Background and overview[1-2] 2-Bromo-1-chloro-4-trifluoromethoxybenzene is a pharmaceutical intermediate, which can be prepared from 2-bromo-4-(trifluoromethoxy)aniline after diazotization and chlorin…
Preparation of 3-amino-4-chlorobenzonitrile_Kain Industrial Additive
Background and overview[1-2] 3-Amino-4-chlorobenzonitrile is a pharmaceutical intermediate. It can be nitrated from p-chlorobenzonitrile to obtain 4-chloro-3-nitrobenzonitrile, and then reduced to obt…
Preparation of 2-bromo-5-methoxyphenylboronic acid_Kain Industrial Additive
Background and overview[1] 2-Bromo-5-methoxyphenylboronic acid can be used as a pharmaceutical synthesis intermediate and can be prepared from 3-methoxyphenylboronic acid, triphenylphosphine sulfide a…
Preparation and application of ethyl 3-nitrophenyl acetate_Kain Industrial Additive
Background and overview[1] Ethyl 3-nitrophenylacetate can be used as a pharmaceutical synthesis intermediate. It can be prepared by the esterification reaction of 3-nitrophenylacetic acid and ethanol.…
Preparation and application of 1-bromo-3-fluoro-5-pyrrolidinebenzene_Kain Industrial Additive
Background and overview[1] 1-Bromo-3-fluoro-5-pyrrolidine benzene is a pharmaceutical intermediate, which can be prepared by nucleophilic substitution of 1-bromo-3,5-difluorobenzene and pyrrolidine. 1…
Application of ethyl 4-boron-3-chlorobenzoate_Kain Industrial Additives
Background and overview[1] Ethyl 4-boron-3-chlorobenzoate can be used as a pharmaceutical synthesis intermediate and applied in Suzuki coupling reaction. CN107207488 reports that ethyl 4-boron-3-chlor…
Preparation of 4,4′-bis(2-bromoacetyl)biphenyl_Kain Industrial Additive
Background and overview[1] 4,4’-Bis(2-bromoacetyl)biphenyl is a key intermediate in the synthesis of the anti-hepatitis C drug daclatasvir. Daclatasvir is a new hepatitis C drug developed by Bristol-M…
Preparation and application of 1-(3-bromophenyl)pyrrole_Kain Industrial Additive
Background and overview[1] 1-(3-Bromophenyl)pyrrole is an important pharmaceutical intermediate. For example, it can be used to prepare lithium 3-(pyrrolidin-1-yl)benzenesulfinate from 1,3-dibromobenz…
