Latest article
Preparation of (+)-norphenylephrine hydrochloride_Kain Industrial Additives
Background and overview[1] (+)-Norfenefrine hydrochloride, also known as norfenefrine hydrochloride, scientific name m-hydroxyphenylethanolamine hydrochloride, English name NorfenefrineHydrochloride, …
Preparation of 2,2′-bis(trifluoromethyl)diaminobiphenyl_Kain Industrial Additive
Background and overview[1] 2,2′-bis(trifluoromethyl)diaminobiphenyl is also called 2,2′-bis(trifluoromethyl)-4,4’diaminobiphenyl. 2,2′-bis(trifluoromethyl)-4,4’diaminobip…
Preparation and application of 2-nitro-5-chloroaniline_Kain Industrial Additive
Background and overview[1] 2-Nitro-5-chloroaniline is an important pharmaceutical and veterinary drug intermediate. It is currently used in fenbendazole, an upgraded product of the veterinary drug alb…
Preparation and application of 3,5-dihydroxypentylbenzene_Kain Industrial Additive
Background and overview[1-2] 3,5-Dihydroxypentylbenzene is an important pharmaceutical intermediate, which was first obtained by degrading lichenic acid (also known as D-usroleic acid and amylyliscoli…
Preparation and application of 5-amino-2-nitrotrifluorotoluene_Kain Industrial Additive
Background and overview[1-2] 5-Amino-2-nitrotrifluorotoluene is an organic intermediate that can be prepared from m-chlorotrifluorotoluene in two steps. There are literature reports that it can be use…
Preparation and application of 5-chloro-2-hydroxyacetophenone_Kain Industrial Additive
Background and overview[1] 5-Chloro-2-hydroxyacetophenone can be nitrated to prepare 5-chloro-2-hydroxy-3-nitroacetophenone. 5-Chloro-2-hydroxy-3-nitroacetophenone is a key drug intermediate for the s…
Preparation of N-(3-methylphenyl)-4-(4-pyridine)-2-thiazolamine_Kain Industrial Additive
Background and overview[1] N-(3-methylphenyl)-4-(4-pyridine)-2-thiazolamine belongs to the 4-pyridyl-2-anilinothiazole (PAT) class of compounds and is effective against renal cell carcinoma (RCC). Cel…
Application of (R)-2-(aminoethyl)-4-chlorophenol_Kain Industrial Additive
Background and overview[1][2] (R)-2-(Aminoethyl)-4-chlorophenol is a chiral organic intermediate, which can be prepared by reductive amination of 2-hydroxy-5-chloroacetophenone and then chiral separat…
Preparation of α-methylbenzonitrile_Kain Industrial Additive
Background and overview[1] α-Methylbenzonitrile, also called 2-phenylpropionitrile, can be used to synthesize 2-phenylpropionic acid, which is widely used in the synthesis of medicines, spices and pes…
Preparation and application of 6,7-dihydro-4(5H)-benzofuranone_Kain Industrial Additive
Background and overview[1] 6,7-Dihydro-4(5H)-benzofuranone is an important pharmaceutical intermediate. It can be prepared by the reaction of 1,3-cyclohexanedione and chloroacetaldehyde aqueous soluti…
