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Preparation of 5-bromobenzo[1,3]dioxole-4-carboxylic acid_Kain Industrial Additive
Background and overview[1] 5-Bromobenzo[1,3]dioxole-4-carboxylic acid can be used as a pharmaceutical synthesis intermediate. It can be prepared from 6-bromo-2,3-dihydroxybenzaldehyde in three steps. …
Synthesis of 5,6-dihydro-3-(4-morpholino-1-piperidinyl)phenyl]-2(1H)-pyridone_Kain Industrial Additive
Background and overview[1] 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidyl)phenyl]-2(1H)-pyridone is a One of the impurities in Pixaban. Apixaban is an oral, selective activated factor X inhibit…
Preparation and application of 3,4-dihydroxyphenylacetic acid methyl ester_Kain Industrial Additive
Background and overview[1] Methyl 3,4-dihydroxyphenylacetate can be used to prepare hydroxytyrosol. Hydroxytyrosol, whose chemical name is 3,4-Dihydroxyphenylethanol, is a hydroxyaromatic compound. Na…
Preparation and application of 2-hydroxy-5-trifluoromethylbenzoic acid_Kain Industrial Additive
Background and overview[1] 2-Hydroxy-5-trifluoromethylbenzoic acid is an organic intermediate that can be prepared by the reaction of 2-methoxy-5-(trifluoromethyl)benzoic acid and iodocyclohexane. Pre…
Preparation and application of 1-benzothiophene-3(2H)-one_Kain Industrial Additive
Background and overview[1] 1-Benzothiophene-3(2H)-one is an organic intermediate that can be prepared by reacting 2-carboxymethylthiobenzoic acid as a starting material. It can be used to prepare Fluo…
Preparation of 2-hydroxy-4,5-dimethoxybenzoic acid phenyl ester_Kain Industrial Additive
Background and overview[1] 2-Hydroxy-4,5-dimethoxybenzoic acid phenyl ester is an important intermediate in the synthesis of 2-aminothiazole compounds. 2-Aminothiazole compounds are an important class…
Preparation of 1-chlorobenzothiazine_Kain Industrial Additive
Background and overview[1][2] 1-Chlorobenzothiazide is a thiazide compound, which is widely used in various fields, such as tricyclic antidepressants and rubber curing agents. Preparation[1-2] Report …
Preparation and application of 2-amino-4-cyanophenol_Kain Industrial Additive
Background and overview[1-3] 2-Amino-4-cyanophenol is a phenolic derivative that can be used as an organic intermediate and can be prepared by one-step reduction of 2-nitro-4-cyanophenol. Preparation[…
Application of 3,4-dihydro-3-hydroxy-4-oxy-1,2,3-benzotriazine_Kain Industrial Additive
Background and overview[1] 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine is a heterocyclic organic compound and a polypeptide synthesis condensation agent, referred to as HOOBt. Compared with urea s…
Preparation of 4-bromo-2,3-difluorobenzaldehyde_Kain Industrial Additive
Background and overview[1] 4-Bromo-2,3-difluorobenzaldehyde is an important fluorine-containing benzene liquid crystal intermediate. Because the fluorine atom in its structure replaces the hydrogen at…
